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Vitiligo: A Monograph on the Basic and Clinical Science


 

For people with Vitiligo, the first and the most important step in curing the disease is understanding the disease completely. Fear, wrong opinions about the disease and low self esteem will lead to enormous emotional stress and that can worsen Vitiligo.

Take the first step, understand the disease completely, and available treatment options, their effectiveness and latest scientific developments in the treatment procedure through this book. It is a must have for people with vitiligo and can safely be termed as the Vitiligo Bible. However this book is not for the patients without the basic knowledge of biochemistry or immunology.
The Editor’s Review of Vitiligo: A Monograph on the Basic and Clinical Science:

Vitiligo a MonographThis book is a timely, comprehensive monograph about a highly noticeable condition characterized by enlarging areas of cutaneous depigmentation. Current therapies are generally unsatisfactory, and recent advances justify this up-to-date review. The book has a foreword by Aaron B. Lerner of Yale University, founder and developer of modern pigment-cell biology and a pioneer in basic and clinical research in this largely ignored field.

The monograph is well organized, and the excellent choice of topics provides a balanced view of the basic and clinical sciences. The 33 chapters are by recognized experts in the field and are organized into five sections, covering general topics, clinical presentation, pathogenesis (including theories on depigmentation), treatment, and other topics (including depigmentation conditions other than vitiligo and animal models of the disease).

Part 1 contains an interesting chapter on the historical and cultural aspects of vitiligo and ends with a chapter on the genetic aspects of vitiligo vulgaris. Several chapters in part 2 deal with the different clinical forms of vitiligo. The discussions are highlighted by very high quality photographs that convey the range of clinical presentations. This part, which ends with the differential diagnosis of vitiligo, should help both people affected with vitiligo and dermatologists.

Part 3 covers the pathogenesis of vitiligo. There is no dearth of information in this section, which finds room for genetic, autoimmune, autocytotoxic, neural, and biochemical theories. Particularly intriguing are the chapters on the autocytotoxic hypothesis with respect to the disappearance of melanocytes and on the potential role of pteridines as mediators of depigmentation. The discussion of pathogenesis revolves around a common element — the cytotoxicity of intermediates of melanogenesis — but it also mentions the recent newcomers in this field: melatonin and its receptor.

Part 4 covers therapeutic approaches to vitiligo. There are detailed evaluations of photochemotherapy with psoralen compounds in conjunction with ultraviolet A radiation; steroid treatment; epidermal and dermo-epidermal grafting; and transplantation of cultured melanocytes. This assortment of therapies indicates that no single method provides perfect treatment and that, for the most part, the adverse effects are minimal.

Nevertheless, cosmetic approaches, such as micropigmentation of small vitiliginous areas or pharmacologic depigmentation for extensive vitiligo, are the treatments of choice. Success in repigmentation has been reported with topical pseudocatalase and calcium in combination with low doses of ultraviolet B radiation. The last chapter in part 4 discusses alternative therapies for vitiligo, but it recites facts and is short on interpretation and recommendations.

Finally, part 5 covers a variety of topics that are peripherally related to vitiligo. Although each chapter in this part of the book is exhaustive, the random grouping of topics interferes with the flow of reading. Better organization and more background information would be desirable for an audience of practicing dermatologists.

Since readers of this book should have a basic knowledge of biochemistry, pathology, and immunology, it is probably not for the patients without basic knowledge in these topics. It presents updated information on melanin pigmentation and on recent advances in therapy, without excluding the more traditional clinical approaches to the diagnosis and management of this disease. In addition, the graphs and tables are exceptional in quality and scope. In general, this book is an excellent source of information on all aspects of vitiligo and fills a gap in the medical literature.

Andrzej Slominski, M.D., Ph.D.
Our Review:

This book is extremely well organized and the number one choice for people with Vitiligo. It gives a well balanced insight in the basic and highly advanced clinical sciences. It is one of the most important literature on vitiligo even  for dermatologists, dermatopathologists and general doctors as well.